Sekretin

Sekretin
Identifikatori
Aliasi
Vanjski ID-jevi	GeneCards: [1]
Ortolozi
	n/a
	n/a
	n/a
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Sekretin je hormon koji regulira homeostazu vode u cijelom tijelu i utiče na okruženje dvanaestopalačnog crijeva, regulirajući sekrete u želucu, gušterači i jetri. To je peptidni hormon proizveden u S-ćelijama duodenuma, koji se nalaze u crijevnim žlijezdama.^[1] Kod čovjeka, sekretinski peptid kodira gen SCT, koji se nalazi na hromosomu 11.^[2]

Sekretin pomaže u regulaciji pH duodenuma tako što

(1) inhibira lučenje želučane kiseline iz parijetalnih ćelija želuca i
(2) stimulirajući proizvodnju bikarbonata iz kanalnih ćelija gušterače,^[3]^[4] Također stimulira proizvodnju žuči u jetri; žuč emulgira masti u dvanaestpalačnom crijevu, kako bi na njih mogla djelovati pankreasna lipaza. U međuvremenu, u skladu s djelovanjem sekreta, drugi glavni hormon koji istovremeno luči dvanaestopalačno crijevo, holecistokinin, stimulira žučni mjehur da se kontrahira, isporučujući svoju skladištenu žuč iz istog razloga.

Prosekretin je preteča sekreta, koji je prisutan u probavi. Sekretin se čuva u ovom neupotrebljivom obliku, a aktivira ga želučana kiselina. To neizravno rezultira neutralizacijom duodenumskog pH, čime se osigurava da gore navedena kiselina ne ošteti tanko crijevo.^[5]

U 2007., otkriveno je da sekretin ima ulogu u osmoregulaciji, djelujući na hipotalamus, hipofizu i bubrege.^[6]^[7]

^ Häcki WH (1980). "Secretin". Clinics in Gastroenterology. 9 (3): 609–32. PMID 7000396.
^ Kopin AS, Wheeler MB, Leiter AB (1990). "Secretin: structure of the precursor and tissue distribution of the mRNA". Proceedings of the National Academy of Sciences of the United States of America. 87 (6): 2299–303. Bibcode:1990PNAS...87.2299K. doi:10.1073/pnas.87.6.2299. JSTOR 2354038. PMC 53674. PMID 2315322.
^ Whitmore TE, Holloway JL, Lofton-Day CE, Maurer MF, Chen L, Quinton TJ, Vincent JB, Scherer SW, Lok S (2000). "Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA". Cytogenetics and Cell Genetics. 90 (1–2): 47–52. doi:10.1159/000015658. PMID 11060443.
^ 1947-, Costanzo, Linda S. (2006). Physiology (3rd izd.). Philadelphia, PA: Saunders Elsevier. ISBN 9781416023203. OCLC 62326921.CS1 održavanje: numerička imena: authors list (link)
^ Gafvelin G, Jörnvall H, Mutt V (Sep 1990). "Processing of prosecretin: isolation of a secretin precursor from porcine intestine" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6781–5. Bibcode:1990PNAS...87.6781G. doi:10.1073/pnas.87.17.6781. PMC 54621. PMID 2395872.
^ Chu JY, Chung SC, Lam AK, Tam S, Chung SK, Chow BK (2007). "Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption". Molecular and Cellular Biology. 27 (7): 2499–511. doi:10.1128/MCB.01088-06. PMC 1899889. PMID 17283064.
^ Chu JY, Lee LT, Lai CH, Vaudry H, Chan YS, Yung WH, Chow BK (2009). "Secretin as a neurohypophysial factor regulating body water homeostasis". Proceedings of the National Academy of Sciences of the United States of America. 106 (37): 15961–6. Bibcode:2009PNAS..10615961C. doi:10.1073/pnas.0903695106. JSTOR 40484830. PMC 2747226. PMID 19805236.

[pmid7000396-1] Häcki WH (1980). "Secretin". Clinics in Gastroenterology. 9 (3): 609–32. PMID 7000396.

[pmid2315322-2] Kopin AS, Wheeler MB, Leiter AB (1990). "Secretin: structure of the precursor and tissue distribution of the mRNA". Proceedings of the National Academy of Sciences of the United States of America. 87 (6): 2299–303. Bibcode:1990PNAS...87.2299K. doi:10.1073/pnas.87.6.2299. JSTOR 2354038. PMC 53674. PMID 2315322.

[pmid11060443-3] Whitmore TE, Holloway JL, Lofton-Day CE, Maurer MF, Chen L, Quinton TJ, Vincent JB, Scherer SW, Lok S (2000). "Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA". Cytogenetics and Cell Genetics. 90 (1–2): 47–52. doi:10.1159/000015658. PMID 11060443.

[4] 1947-, Costanzo, Linda S. (2006). Physiology (3rd izd.). Philadelphia, PA: Saunders Elsevier. ISBN 9781416023203. OCLC 62326921.CS1 održavanje: numerička imena: authors list (link)

[5] Gafvelin G, Jörnvall H, Mutt V (Sep 1990). "Processing of prosecretin: isolation of a secretin precursor from porcine intestine" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6781–5. Bibcode:1990PNAS...87.6781G. doi:10.1073/pnas.87.17.6781. PMC 54621. PMID 2395872.

[Chu07-6] Chu JY, Chung SC, Lam AK, Tam S, Chung SK, Chow BK (2007). "Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption". Molecular and Cellular Biology. 27 (7): 2499–511. doi:10.1128/MCB.01088-06. PMC 1899889. PMID 17283064.

[Chu-7] Chu JY, Lee LT, Lai CH, Vaudry H, Chan YS, Yung WH, Chow BK (2009). "Secretin as a neurohypophysial factor regulating body water homeostasis". Proceedings of the National Academy of Sciences of the United States of America. 106 (37): 15961–6. Bibcode:2009PNAS..10615961C. doi:10.1073/pnas.0903695106. JSTOR 40484830. PMC 2747226. PMID 19805236.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Sekretin

From Wikipedia, the free encyclopedia · View on Wikipedia